Colchicine Colcrys

June 10, 2011 by Tim.

Colchicine (Colcrys)

Colchicine affects the way the body responds to uric acid crystals, which reduces swelling and pain.

Because colchicine was developed prior to federal regulations requiring FDA review of all marketed drug products, not all uses for colchicine have been approved by the FDA. As of 2009, Colcrys is the only brand of colchicine that has been approved by the FDA.

The Colcrys brand of colchicine is FDA-approved to treat gout in adults, and to treat a genetic condition called Familial Mediterranean Fever in adults and children who are at least 4 years old.

Generic forms of colchicine have been used to treat or prevent attacks of gout, or to treat symptoms of Behcets syndrome (such as swelling, redness, warmth, and pain).

Colchicine is not a cure for gouty arthritis or Behcets syndrome, and it will not prevent these diseases from progressing. Colchicine should not be used as a routine pain medication for other conditions.

To read the full article What is colchicine (Colcrys)? from eMedcineHealth.


Filed under: Gout and Pseudogout.

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Colchicine Gout

June 10, 2011 by Tim.

Cochicine Gout

Colchicine (Colcrys) is taken in tablet form (oral).

How Colchicine Works

Colchicine blocks the inflammation caused by uric acid crystals.

Why Colchicine Is Used

Colchicine has long been used to relieve acute gout attacks. It does not lower the level of uric acid. But in low doses, it does reduce the chance of future gout attacks.

Colchicine may be an option for some people who cannot take nonsteroidal anti-inflammatory drugs (NSAIDs).

To help reduce the number and severity of gout attacks that can result when uric acid levels change suddenly, colchicine may be given at the same time as uricosuric medications, such as probenecid or sulfinpyrazone, which lower uric acid levels, or xanthine oxidase inhibitors, which block uric acid production.

Colchicine is avoided or used with caution in people who have:

Kidney disease.
Liver disease.
Inflammatory bowel disease.
A low white blood cell count.

To read the full article Colchicine for Gout from WebMD.


Filed under: Colchicine Use, Gout and Pseudogout.

Tags: colchicine gout, what is gout, gout information, gout symptoms, causes of gout, gout medication, colcyrs for gout, colchicine information .


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Pseudogout

June 23, 2011 by Lynn.

Pseudogout or "false gout" presents similar symptoms to gout such as pain, swelling, heat, redness and stiffness in the affected area. Like gout, pseudogout affects the joints, most commonly the knees, but also the toes, feet, hands, wrists, arms and shoulders. Also as with gout, there are symptom-free remission periods between attacks.

Although the symptoms are so similar, pseudogout is an entirely different condition than gout. It is even possible to have gout and pseudogout at the same time. While gout primarily affects men over 30 and the occasional post-menopausal woman, pseudogout affects both sexes equally as they age. Pseudogout is occasionally misdiagnosed as osteoarthritis or rheumatoid arthritis.

Although both gout and pseudogout are forms of arthritis, they have one main distinguishing characteristic. While gout is caused by needle-like crystals of uric acid building up in the fluid surrounding the joints, pseudogout is caused by a build up of calcium pyrophosphate crystals - a form of salt. Because of this, pseudogout is sometimes referred to as calcium pyrophosphate dihydrate deposition disease, or CPPD disease. While the calcium deposits cause gout-like symptoms, they do not form gout tophi as uric acid crystals do.

Attacks of pseudogout are often precipitated by dehydration, commonly occurring in elderly patients following surgery. It can also be associated with an injury or illness, including hormonal disorders, hemophilia, hemochromatosis, ochronosis, and amyloidsis. The condition can also be inherited.

A diagnosis is made by examining fluid drawn from the joint to determine if it contains uric acid crystals or crystals of calcium pyrophosphate. As well, x-rays of the affected joint may reveal calcium deposits or calcification of cartilage. Pseudogout's tendency to calcify cartilage can cause permanent joint and nerve damage if left untreated.

It's not known what causes pseudogout. Like gout, there is no cure or preventative treatment, but most patients respond well to treatment. Applying ice and resting the affected joint can help reduce inflammation and dull the pain.

Pseudogout can be treated with NSAIDs, COX-2 inhibitors, oral and injected corticosteroids, dietary changes and draining of the affected joint. Colchicine is often prescribed for both treatment of acute attacks and long-term prevention of recurrent attacks.


Filed under: Gout and Pseudogout.

Tags: gout arthritis, pseudogout, false gout, gout treatment, gout pain relief, colchicine medication, buy colchicine, colchicine colcyrs.


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Colchicine for Gout

June 29, 2011 by Lynn.

If anti-inflammatories don't work well enough, or you are unable to take them, your doctor will likely prescribe colchicine (brand name Colcrys). The name colchicine comes from the Greek word for autumn crocus, kolchikon. The autumn crocus, also known as meadow saffron, has been used as a gout medication for about 2000 years. The medicine is derived from the dried seeds or bulb - the rest of the plant is highly poisonous.

Colchicine was first isolated from the autumn crocus in 1820. The colchicine mechanism of action is different from other painkilling and anti-inflammatory drugs. Colchicine acts by binding to a small globular protein called tubulin and interfering with immune system first-responder inflammatory white cells called neutrophils, reducing inflammation.

Colchicine has both pain relieving and anti-inflammatory effects, although it's most powerful as an anti-inflammatory. Therefore, colchicine can treat gout in two different ways, at higher doses to treat the pain and inflammation of an acute attack, or at lower doses to prevent recurring attacks. While colchicine can reduce the attacks of gout, it does not prevent the accumulation of uric acid that can lead to gout attacks and joint damage.

It has been widely available as colchicine tablets since the 1930's, and was FDA approved in combination with probenicid (a gout medication which increases uric acid excretion) in the early 1980's. Colchicine was approved as a solitary gout drug in 2009 under the brand name Colcrys.

Colchicine can also be administered intravenously, but IV use should be restricted to hospitalized patients under the care of a doctor because of the potential for toxicity.

Colchicine is best known as an effective gout medication, but it is also used to treat pseudogout, and has been approved for the treatment of familiar Mediterranean fever (FMF). FMF is a rare inherited disorder that causes recurring attacks of fever and inflammation. Less commonly, colchicine is prescribed to treat amyloidosis, cirrhosis, pericarditis, Paget's Disease and Behcet's Disease.

Some naturopaths use the gout medication off-label as a treatment for a number of conditions, including back pain. Colchicine can also be used in combination with another anti-inflammatory to treat irritable bowel syndrome, and is being investigated as a treatment for cancer.

Colchicine Dosage

Colchicine is available in .05, .06 and 1 mg colchicine tablets. Individual colchicine dosage is based on your medical condition, medical history and response to therapy, and should be decided by your doctor.

The usual initial dose of colchicine for gout during an acute attack is 1 or 1.2 mg. This initial dose is usually followed by half doses of gout medication every hour or full doses every two hours until the pain is relieved, then lowered to .5 or .6 mg every two to three hours. The colchicine dosage may be lowered or stopped if the patient experiences gastrointestinal symptoms such as nausea or diarrhea.

The colchicine dosage for gout prevention varies depending on individual circumstances and the number of gout attacks experienced, but is usually between .5 mg three times a week to .6 mg daily.

If you are taking colchicine regularly and you miss a dose, take it as soon as possible. But if it is almost time for your next dose, skip the missed dose and take your next dose as usual - don't double dose.


Filed under: Gout and Pseudogout.

Tags: colchicine for gout, gout medication, gout drug, colchicine tablet, generic colchicine, colchicine dosage.


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Jim Belushi Helps Launch Gout Awareness Campaign

November 9, 2011 by Estella.

about his battle with gout
about his battle with gout
Jim Belushi has joined with Savient Pharmaceuticals to launch a new educational campaign called "Check Out Your Gout". The campaign is aimed at raising awareness about gouty arthritis, and a severe form of the condition known as refractory chronic gout, or RCG. An actor, singer and performer, Belushi's roles have ranged from comedy to drama, but when it comes to gout, Belushi is completely serious.

"When I first developed gout, I didn't want to do anything about it. I thought I could tough it out; but when the pain became too unbearable for me to perform on stage, I saw a rheumatologist and got my gout under control," said Belushi. "I am taking part in the 'Check Out Your Gout' campaign to let people know that gout is a very painful condition that should be taken seriously, and to tell those who are or may be affected by gout or RCG to check it out and work with a doctor to identify the best management plan."

The campaign encourages people to get serious about gout and to take action to learn more about the condition. The campaign features broadcast and online videos, as well as an educational website, CheckOutYourGout.com.

Gout is a debilitating form of arthritis affecting approximately eight million Americans. Triggered by high levels of uric acid in the blood, gout causes pain and swelling in the joints and can result in deposits of uric acid crystals under the skin, called tophi. RCG occurs when uric acid levels remain high and symptoms persist despite available conventional therapies. RCG symptoms may be particularly debilitating, due to the frequency and severity of episodes, the recurrent painful gout attacks and the disfigurement associated with the condition.

As part of the campaign, Belushi will share his personal experience with gout through national and local media appearances and additional programming planned for next year. "Gout continues to be widely misperceived and overlooked," said Louis Ferrari, Senior Vice President of Savient Pharmaceuticals. "Our hope is that through the 'Check Out Your Gout' campaign Savient, together with Jim, can increase awareness and understanding of gout and RCG."

Savient Pharmaceuticals manufactures and markets the first and only FDA-approved gout medication to treat adults with chronic and severe gouty arthritis that doesn't respond to existing gout drugs. Unlike older oral gout medications such as prescription colchicine, Krystexxa (pegloticase), is given intravenously (into a vein). The pegloticase mechanism of action is different than that of other gout medications, which block the production or increase the excretion of uric acid. Instead, Krystexxa converts uric acid to a nontoxic byproduct that is easily excreted in the urine.


Filed under: Gout and Pseudogout.

Tags: buy colchicine, gouty arthritis, gout medication, gout drugs, gout medications, prescription colchicine, pegloticase mechanism of action.


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Can Magnet Therapy Relieve Gout Pain?

October 10, 2012 by Teresa.

The debilitating pain of gout can be very difficult to deal with on a daily basis. When experiencing a flareup, most people will do almost anything to achieve some relief. There are a number of non-medical and medical therapies available to help manage the symptoms of pain, but is it true that magnets have the power to reduce pain?

Magnet therapy or bioenergy therapy operates on the principle of the magnet's ability to correct bodily energy. According to this theory, when your body is healthy it produces electromagnetic impulses. However, when a person is in pain, those impulses experience an interference. Those who believe in the benefits of magnet therapy suggest that the magnets can correct these abnormalities in the body. Increased blood flow and oxygen flow is also a reported benefit. When the body is balanced, the pain is reduced.

Magnetic therapy can be applied in various forms including magnetic straps or wraps, jewelry, and magnetic implants in pillows and mattress pads. There are different strengths of magnets on the market. The more powerful magnets can be a tad expensive. The use of these magnetic aids may reduce the pain, inflammation, and swelling that is brought on by a gout attack, headaches, general body aches from arthritis, and fibromyalgia.

Although most of the reports of success are anecdotal in nature, none of these claims have been studied nor does the US Food and Drug Administration support the claims. The American Cancer Society's position on magnetic therapy is the same. At this point, it is inappropriate for companies that manufacture these pain aids to make claims that their products can cure diseases. However, there is a growing number of people who have made use of these simple pain aids and claim to have experienced a reduction in their discomfort.

There are companies that offer a money back guarantee for their products. When trying to decide whether or not to give magnetic therapy a try, consider ordering from a company or local store that provides this kind of safety net. You don't have to worry about taking any drugs like Colchicine for gout treatment. Magnetic therapy is a drug free alternative with no harmful side effects.


Filed under: Gout and Pseudogout, Alternative Gout Treatment, New Study.

Tags: magnet therapy, pain of gout, gout attack, arthritis, fibromyalgia, colchicine for gout, gout treatment, magnetic therapy.


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Understanding the Difference between Gout and Pseudo-gout

May 15, 2013 by Mayank.

Have you ever wondered why are you having red, swollen joints in your body which are causing you great pain? You may think, it is Gout, but many a times it might not be true, and it may rather turn out to be pseudo-Gout. Because many symptoms are same for both the conditions, many a times one is mistaken for the other. However, it is essential to diagnose the condition accurately so as to get proper, respective treatment for the same.

Over the period of time, calcium pyrophosphate dehydrate (CPPD) crystals gets deposited in your body joints, that gives rise to the condition of pseudo-Gout. The high volume of uric acid in the body supports the rise of these crystals in the joints. These pseudo-Gout characteristics differ from the normal Gout in terms of the crystal formations. Pseudo-Gout is also often referred as pyrophosphate arthropathy. Finding out the distinction between the Gout and the pseudo-Gout is important to begin the treatment accordingly.

The key differences between the Gout and the pseudo-Gout can be summed up under the following headings:

Joints

Pseudo-Gout majorly affects the larger joints in the body such as the knee, elbow, hip, shoulders and wrists. Gout, on the other hand, usually affects the smaller joints in the body like the toes.

X-ray

In case of pseudo-Gout, the radio waves clearly show the calcification in the cartilage of the joints in the body. Chondrocalcinosis is the scientific term used for the calcification of the joint cartilage. On the other hand, there is no calcification in case of regular Gout.

Crystals

The calcium pyrophosphate dehydrate crystals, observed in case of the joints affected by the pseudo-Gout, are rhomboid is shape. The liquid floating in the joints is observed with the help of a microscope to come to this conclusion. Whereas the monosodium urate, found in case of the joints affected by Gout, are usually needle shaped or of the shape of a spindle.

Also, positive birefringence of crystals under polarized light are observed when the pseudo-Gout affected joints are observed under the microscope. On the other hand, the Gout crystals display negative birefringence of crystal when observed under the polarized light. Regular drugs like indomethacin and Ibuprofen are the common drugs which are used to reduce the pain suffered by the gout and pseudo gout patients. Another drug used in case of Gout is Colchicine. Colchicine helps to reduce the pain causing agents in the blood cells. In case you are affected by Pseudo-Gout and your bigger joints are affected by it, you can intake high dosage of Colchicine to alleviate pain.

Medication

While drugs like allopurinol, sulfinpyrazone and probenicid work well in case of regular Gout, these drugs are ineffective when it comes to pseudo-Gout. These drugs help in suppressing CPPD crystals in the joints and form urate crystals instead.

Making a distinction between Gout and Pseudo-Gout is quite a difficult task. It becomes all the more critical considering the fact that there are separate treatments for Gout and Pseudo-Gout. The differences mentioned above in the article are sure to help you out while you are trying to distinguish between Gout and Pseudo-Gout. Another point to be kept in mind is that both these conditions can still be mixed up with inflammatory arthritis and other similar diseases.


Filed under: Gout and Pseudogout.

Tags: gout and pseudo-gout, affected by gout, gout crystals, gout drugs, colchicine, dosage of colchicine, gout treatment.


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