Colchicine Gout

June 10, 2011 by Tim.

Cochicine Gout

Colchicine (Colcrys) is taken in tablet form (oral).

How Colchicine Works

Colchicine blocks the inflammation caused by uric acid crystals.

Why Colchicine Is Used

Colchicine has long been used to relieve acute gout attacks. It does not lower the level of uric acid. But in low doses, it does reduce the chance of future gout attacks.

Colchicine may be an option for some people who cannot take nonsteroidal anti-inflammatory drugs (NSAIDs).

To help reduce the number and severity of gout attacks that can result when uric acid levels change suddenly, colchicine may be given at the same time as uricosuric medications, such as probenecid or sulfinpyrazone, which lower uric acid levels, or xanthine oxidase inhibitors, which block uric acid production.

Colchicine is avoided or used with caution in people who have:

Kidney disease.
Liver disease.
Inflammatory bowel disease.
A low white blood cell count.

To read the full article Colchicine for Gout from WebMD.

Filed under: Colchicine Use, Gout and Pseudogout.

Tags: colchicine gout, what is gout, gout information, gout symptoms, causes of gout, gout medication, colcyrs for gout, colchicine information .

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Effective Colchicine Therapy for Recurrent Pericarditis

November 25, 2011 by Derek.

Heart Smart
Heart Smart
Inflammation of pericardium, the fibrous sac enclosing the heart, is a medical defect known as pericarditis. Patients often experience chest pain, swelling in the ankles and feet. Shortness of breath while lying down and anxiety are other symptoms. Our Canada pharmacy found more people purchase colchicine to prevent recurrent pericarditis.

Colchicine is an oral drug used to treat gout and familial Mediterranean fever (FMF) and is useful in suppressing inflammation. A recent trial now finds the prescription drug more effective than placebo in preventing recurrent and persistent symptoms of pericarditis in conjunction with conventional therapy. A double-blind multicenter randomized trial, the first of its kind, demonstrates effectiveness of the medication.

Trial Conducted To Verify Non-Randomized Observational Findings
Pericarditis has a common complication in that it is recurrent in about 20% to 50% cases of people who have experienced the medical condition earlier. Recurrent pericarditis is a disabling disease seriously affecting quality of life. Frequency at which it occurs makes re-hospitalization necessary. Efficient management is needed to keep treatment costs down. Open-label randomized studies conducted at two centers and non-randomized observational findings already revealed effectiveness of colchicine in preventing recurrent pericarditis. Experts were therefore of the opinion further tests were needed to verify results. Our Canada pharmacy followed up on the multi-center trial.

Experts from the European Society of Cardiology recommended colchicine in its 2004 guidelines for pericardial diseases, which initiated the CORP trial in four centers in Italy. The trial was conducted on 120 consecutive patients who experienced pericarditis for the first time. A primary endpoint was set up to check recurrence of pericarditis at the end of 18 months.

Several secondary endpoints were also set up. Recordings included checks to measure persistence of symptoms at the end of 72 hours, number of times the condition occurred, rate of remission at the end of the week, first recurrence, rate of constrictive pericarditis, cardiac tamponade, and hospitalization due to pericarditis.

Volunteers were given an initial dose of 1 to 2 mg on the day of starting the trial followed by 0.5 to 1 mg daily for the next six months. The lower initial and maintenance dozes were given to people below the rate of 70 kg and those who demonstrated intolerance to higher doses.

Positive Results Encourage Usage of Colchicine
Trial results clearly indicated colchicine was more effective than placebo. For example, the 18-month recurrence rate reduced by 55% in the case of colchicine compared to just 24% in the case of placebo. The mean number of recurrent episodes also reduced in favor of colchicine. At the end of 72 hours, persistent symptoms were 23% compared to 53.3% in placebo cases. Also, people found faster relief in 82% cases compared to 48% in people using placebo.

Colchicine is known to be a safe drug available at low cost at a Canada pharmacy. Further trials may be needed including people from other geographical locations and in more generalized settings; however, the prescription drug does provide rapid relief from symptoms of pericarditis. Its effectiveness over the 18-month period makes it an ideal medication to be added to empiric anti-inflammatory therapy for prevention of recurrent pericarditis.

Filed under: Colchicine Use, Recurrent Pericarditis.

Tags: colchicine, therapy, recurrent pericarditis, CORP, gout medication, buy colchicine.

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New Research Shows Colchicine May Help Fight Cancer

February 3, 2012 by Shelly.

Treating Cancer with minimal damage to the patient's health is a constant battle for researchers and scientists developing new cancer fighting drugs. Finding a drug that targets only the infected cells in our body and does not harm otherwise healthy tissue is not an easy quest, but is the driven work of Professor Laurence Patterson, Director of the institute of Cancer Therapeutics at the University of Bradford, and his team.

Patterson's team are developing a new therapy that is based on the chemical Colchicine; a drug that is currently being used most commonly to treat gout.

Colchicine - a compound derived from the Autumn Crocus, the team believes that this is the first attempt at removing existing blood vessel supply to a tumour. Using an enzyme, only found in diseased tissue as a trigger means that it can also target secondary tumours caused by the cancer spreading through the body.

Their starting point was a batch of Matrix Metalloproteinases called MMP14, which had been identified in tumour tissue. This enzyme breaks down the proteins in surrounding healthy tissue and allows the tumour to proliferate. When the tiny molecules of the drug meet the MMP14 they combine to activate the drug.

Destroying Cancer's lifeline
The tumour grows by getting its nutrients from the body. So if you can destroy the vasculator that the tumour has, then you starve it of oxygen and nutrients. Professor Patterson explains, 'we knew there were these disrupting agents but they weren't targeted. The ones that were being trialled would work where they were absorbed so one of the areas where their toxicity was high was the heart. These drugs hadn't progressed because of this. That's what's so exciting about what we have achieved. Every tumour that we have looked at expresses this enzyme MMP14 and the reason why they all express it is because all tumours that are confined within their original normal tissue environment need to break out of that environment, it's an enzyme that has benefit to all tumour types.'

Clinical trial
Although the chemical, Colchicine is a natural derivative, the team are manufacturing it in the laboratory. The have established the concept and provided supporting evidence for the research, so once that funding has been established, they will begin the next phase of to develop the drug and begin clinical trial.

The beauty of this drug, Patterson says is its compatibility with conventional treatments such as chemotherapy. Taking into account the resistant nature of tumours, Colchicine promises another weapon in the body's battle, cutting off the blood supply that allows the cancer to flourish, so even an aggressive cancer could be neutralised.

Filed under: Colchicine Use, Cancer.

Tags: colchicine, research on colchcine, colchicine for cancer, colchicine therapy, colchicine drug,

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The Story of Colchicine

April 13, 2012 by Julia.

Colchicine Tonic
Colchicine Tonic
Check out this awesome article from the Lancet about the history of gout and the rise of colchicine! It came into use over 200 years ago! Gout also used to be considered a sign of status - only those who ate more expensive foods and lived more sedentary lifestyles would develop gout.

Once gout was seen often in the population, 18th century doctors began mixing cocktails reputed to stop or prevent gout. Most of them were made with an alcohol base, which we know now must have made the flare-ups worse! Luckily for 18th century gout sufferers, eventually an American colonial doctor added a local plant to his tonic...that plant turned out to contain colchicine.

If your doctor prescribes colchicine for gout, consider buying online at a Canadian pharmacy. You can buy Colcrys for significantly less online than you would pay at an American pharmacy.

View "Bitter medicine: gout and the birth of the cocktail" on the Lancet's website here.

Filed under: Buy Colchicine, Colchicine Use, What is Gout, Gout Fact, Gout Resources.

Tags: story of colchicine, history of gout, develop gout, gout flare up, prevent gout, colchicine for gout.

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Colchicine for Canker Sores?

July 2, 2012 by Julia.

Colchicine Treatment
Colchicine Treatment
An article regarding the extraneous uses of colchicine recently reminded doctors of another option for chronic canker sores. Canker sores are also called aphthous ulcers. They are small, shallow lesions that develop on the soft tissues in your mouth or at the base of your gums. Unlike cold sores, canker sores don't occur on the surface of your lips and aren't contagious. They can be painful, however, and can make eating and talking difficult.

Treatment usually isn't necessary for minor canker sores, which tend to clear on their own in a week or two. But large, persistent or unusually painful sores often need medical care. A number of treatment options exist, ranging from mouth rinses and topical ointments to systemic corticosteroids for the most-severe cases. Check with your doctor or dentist if you have unusually large or painful canker sores or canker sores that don't seem to heal.

Although most people will not experience these painful canker sores, for those who have Behcet's disease, or another condition with canker sores as a symptom, they will try anything in order to get rid of them. For simple canker sores, a rinse with warm water and salt is useful, or for slightly more severe sores, an antibiotic moth rinse is often prescribed. But when these don't work, doctors start trying different medications. Although doctors are unsure why generic colchicine works, it has been used to treat painful canker sores in hundreds of people. A small study in India was completed with good results, but government health organizations will require larger, double-blind, controlled studies before allowing an official change to colchicine's label. In the United States, colchicine is currently only approved for gout treatment and familial Mediterranean fever, a rare inflammatory disease.

Colchicine is sold in the United States under brand name Colcrys. Although colchicine has been around for years, as it is plant-based, it is extremely expensive in the United States. There is a monopoly on the market, as only one manufacturer, URL Pharma, is allowed to produce it in the United States. For those who desperately need this helpful medication, but can't afford it, consider shopping online.

Filed under: Colchicine Generic, Colchicine Use.

Tags: colchicine treatment, uses of colchicine, url pharma, canker sore, canker sore treatment, generic colchicine, brand name colcrys.

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Colchicine and Watermelons

August 29, 2012 by Julia.

Colchicien and Watermelon
Colchicine and Watermelon
What do watermelons and colchicine have in common? They are combined to create seeded watermelons.

Colchicine, a derivative of the autumn crocus, which is also used to treat gout, is added to the watermelon seedlings before they flower. This causes the watermelon eggs to produce an incorrect amount of chromosomes, resulting in seedless watermelons. Seedless watermelons (which do not contain the hard, black seeds needs for reproduction) can not reproduce - similar to a mule. A mule is the progeny of a horse and a donkey, which is sterile.

Seedless watermelons, although they seem like an amazing new genetically modified melon, aren't genetically modified at all; they simply are reacting to the introduction of colchicine to their reproductive cycle. Read more on The Salt, NPR's food blog.

Remember to ask your doctor for a prescription for colchicine 0.6mg if you have gout. It is still one of the most natural and highly prescribed gout medications on the market today. But since there may be only one manufacturer in your area, you may be charged an exorbitant price. Shop online at an international pharmacy for more affordable colchicine.

Filed under: Cochicine 0.6 mg, Colchicine Use, Gout Medications.

Tags: colchcine 0.6mg, canadian pharmacy,.

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Cryotherapy for Arthritis

September 3, 2012 by Julia.

Cryotherapy for Arthritis
Cryotherapy for Arthritis
A new type of arthritis therapy has recently been approved in the United Kingdom. A type of 'pen' that uses super-cold temperatures to stop pain signals could provide relief for thousands of arthritis patients. The handheld device contains a tiny needle-like tip that is cooled to minus 20c this is inserted just a few millimetres under the skin against a nerve. The theory is that the cold temperature makes nerves 'hibernate' so that the pain signals are blocked.

The new gadget which is the size and shape of a pen could also work for a wide range of conditions, say the manufacturers, including headaches, arthritis, facial pain and carpal tunnel syndrome. The therapy can be repeated continually in a GP surgery or pain clinic. Cold temperatures are increasingly being employed by doctors to treat a range of pain conditions.

The treatment is called cryotherapy, and is thought to work by blocking the ability of nerve fibres to transport signals. The conduction of signals along our nerves involves the coordination of a number of complex chemical reactions. It's thought that cold temperatures can slow the rate of these reactions, and lead the nerves to become 'quiet' and stop sending signals. This is partly why our hands and feet go numb in cold temperatures (the cold also causes blood vessels in the extremities to shrink, further adding to the numb sensation).

The cryotherapy pen uses cold liquid nitrogen to chill the tip. When the pen is switched on, the cold liquid inside the device is put under high pressure, which causes it to turn into a super-cold gas. This gas then cools the metal tip. A doctor places the tip which is the same thickness as a needle into the patient's skin, which cools the surrounding tissue in a matter of seconds. Sensors in the device monitor the temperature of the skin throughout the treatment, to ensure the tip is cold enough to send the nerves into 'hibernation', but not so cold that it could damage the tissue.

Each treatment session takes around 30 to 45 minutes. It can be repeated as often as required, and the researchers say that the effects last for differing times depending upon the condition that is being treated. Clinical trials are still ongoing, but early data from more than 100 patients already shows that the system can be effective. As well as investigating its use for pain disorders, researchers are also looking into whether the device could work on nerves that control movement. They hope that this will enable it to be used for conditions that cause upper limb spasticity such as stroke, multiple sclerosis or Parkinson's. These disorders cause nerve damage, which triggers uncontrolled muscle activity such as clenching, twitching or spasm.

The cold pen has the potential to deactivate the malfunctioning nerves and block the uncontrolled muscle activity. Clint Carnell, chief executive of U.S.-based Myoscience, which developed the device, said: 'We currently have studies looking at its effectiveness for pain and for movement disorders and if all goes well we would hope to launch in the UK in 2013.'

Until the cryotherapy pen is approved around the world, arthritis sufferers, especially those with gout, should ask their doctors about colchicine 0.6mg, a gout treatment that has been available for hundreds of years. Although it is made from a relatively common plant, the autumn crocus, it could be extremely costly at your local pharmacy. International and Canadian pharmacies with different health care plans are able to offer colchicine for significantly less that can be found at your local pharmacy.

Filed under: Cochicine 0.6 mg, Cochicine Canada, Colchicine Use, Alternative Gout Treatment.

Tags: colchicine 0.6mg, canadian pharmacy, cryotherapy, canadian pharmacies, pain relief.

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