Are Your Medications Affecting Your Gout?

March 7, 2012 by Julia.

antihypertensive meds
antihypertensive meds
A new study has been posted detailing the effects of certain hypertension medications on gout. Researchers based out of the Boston University of Medicine have released the results of their study comparing hypertension (blood pressure) medications and gout. Many gout sufferers also have high blood pressure, and are often placed on anti-hypertension medications along with their gout medication. The new research states, however, that the medications they are on may actually increase their chances of gout and gout flares, with only a few anti-hypertension medications being seen to lower the chances of gout.

The research has shown that hypertension medication such as diuretics, beta blockers, ACE inhibitors and some angiotensin II receptor blockers are likely to raise a patient's risk of gout. However, calcium channel blockers and losartan were shown to reduce the chance of gout.

The group of drugs seen to raise the risk of gout include such popular medications such as Teveten, Lasix and Accupril. These are considered to raise the risk of gout as these medications raise the levels of uric acid in the body. It is a buildup of uric acid in the joints, which then crystallizes, causing the painful inflammation known as gout.

On the other hand, the researchers believe that losartan and calcium channel blockers' penchant to reduce the risk of gout is because of their effects on the kidneys. Uric acid, instead on building up in the joints, is flushed through the kidneys and out of the body when the patient uses these types of anti-hypertension medications. Losartan was shown to reduce the body's uric acid levels by up to 25%.

The researchers' findings should be used as a guide for doctors to decide which hypertension medications might work best for their patients. As high blood pressure is already a risk factor for gout, talk to your doctor about a prescription for Hyzaar or Zestril.


Filed under: Gout Risk.

Tags: hypertension medications, gout sufferers, medications affecting gout, gout inflammations, risk of gout, buy hyzaar, colchicine.ca.


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New Gout Medications in Clinical Trials

March 15, 2012 by Julia.

Peramivir or Lesinurad
Peramivir or Lesinurad
Biocryst Pharmaceuticals and Ardea Pharmaceuticals are racing to bring a new gout drug to the American market. According to the most recent reports, Ardea's version is currently "winning." Of course, the winners here will be gout patients, who will be served by the best medication for their condition.

Biocryst's version is called peramivir, which is used for allopurinol-resistant forms of gout. Participants in the company's clinical trial took their regular dose of allopurinol, and were given doses four times daily of either peramivir or a placebo. After 12 weeks, subjects who took peramivir reported a 33 to 49 percent response rate compared to only 18 percent reported by those who took a placebo plus allopurinol. This is potentially exciting news, until you learn more about Ardea's contribution to the field of gout medicine.

Ardea Pharmaceutical's experimental gout drug, called lesinurad, had a reported 70 to 80 percent response rate compared to 28 percent for those using a placebo. Peramivir (Biocryst) also had an extremely high toxicity rate, which caused some participants to drop out of the study due to significantly reduced levels of CD4 immune cells. The goal of most gout medications is to reduce uric acid levels without significantly affecting the rest of the body. Many gout sufferers have hypertension or other ailments. Gout medication developers need to take this into consideration when creating a compound, which makes it difficult.

One of the best medications for gout, colchicine, has been around for years (it is derived from a plant, the autumn crocus). However, recently the FDA took away approval from almost all manufacturers. This has caused a once-cheap medication to skyrocket in price. However, savvy patients know that they can get Colcrys online, from a Canadian online pharmacy. The Canadian government regulates medication pricing, which keeps prices low. American consumers can take advantage of this significant price difference by buying online with a Colcrys prescription.


Filed under: New Gout Drug.

Tags: gout medication, new gout drug, biocryst pharm, ardea pharm, gout suffers, colchicine for gout, buy colcrys online, colcrys prescription.


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Colchicine Cuts Heart Attack Risk in Half

March 28, 2012 by Julia.

Autumn Crocus-Colchicine
Autumn Crocus-Colchicine
According to a new retrospective study released by the New York Veteran Affairs Gout Cohort, gout sufferers who use colchicine have half the risk of a myocardial infarction (heart attack) compared to an untreated gout sufferer. This protection was not found in gout sufferers who used allopurinol.

Researchers studied 1300 gout patients to come up with their conclusions. They found that 0.5% of colchicine users had a heart attack, versus 3 percent of untreated gout users. The rate of MI was only two percent for allopurinol users, not a significant difference. Researchers believe that this may be due to allopurinol's inconsistency at lowering urate levels.

The lead researcher, Dr. Pillinger, stated that "these are very provocative findings." He hopes to begin a prospective study, once he and his team have completed a more rigorous retroactive study.

Colchicine is one of the most common treatments for gout. It is derived from a plant, the autumn crocus, and has been used as a gout treatment for hundreds of years. Unfortunately, it is only available in the US from one American manufacturer, and as such, it is much easier to buy Colcrys cheap at an online Canadian pharmacy than an American pharmacy. American gout sufferers can take advantage of this price difference by buying online. We recommend BigMountainDrugs.com, which is fully licensed and based in Vancouver.

You can view the original release here.


Filed under: Buy Colcrys.

Tags: colchicine use, colchicine users, heart attack, heart risk, gout sufferers, allopurinol, treatment for gout, gout treatmet, buy colcrys cheap.


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