Does Insulin Resistance Cause Gout?

August 4, 2011 by Lynn.

It's commonly believed that the excess uric acid that causes gouty arthritis results from problems with purine metabolism and/or overindulgence in purine rich foods.

Another less well known theory is that high uric acid levels are caused by, or associated with, insulin resistance (a pre-diabetic condition in which insulin becomes less effective at controlling blood sugar).

It is well known that gout sufferers are at increased risk of diabetes, and vice versa. Several studies have demonstrated that insulin inhibits the elimination of uric acid through the kidneys.

South African researchers looking at the possible connection between insulin resistance and high uric acid put thirteen gout sufferers on a diet known to combat insulin resistance, the Zone Diet. None of the study participants were taking uric acid lowering gout medication.

During the four-month study period, the participants' monthly gout attacks dropped an impressive 70 percent. To read more about the gout diet study on best-gout-remedies.com, >CLICK HERE.<


Filed under: Gout Causes and Symptoms, Gout Risk.

Tags: insulin resistance, long acting insulin, gout causes, gout risks, gout medications, colchicine, colcrys, buy colchicine canada.


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CDC Website Contains Unique Gout Information

August 5, 2011 by Estella.


The Centers for Disease Control and Prevention (CDC) official website is a respected online source of credible health information. The CDC website has an in-depth page on gout in its Arthritis Types section that contains information not always found on other information sites.

Topics include:

The page ends with a list of ten more online gout resources. Check out the page on the CDC website.


Tags: colchicine, colcrys, gouty arthritis, gout medications, colchicine for gout, gout drug, gout information, gout resources.


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Advanced Medical Imaging Technique Can Diagnose Gout

August 8, 2011 by Lynn.

A medical imaging technique called dual-energy computed tomography (CT) is proving to be a reliable method to diagnose acute gout in a hospital emergency room setting. The technique can detect vessels and bones and display them in contrast to one another more clearly than conventional imaging techniques.

The technique is being used in Vancouver, BC in Canada, where doctors say it leads to earlier diagnosis and improved gout treatment. To read more about diagnosing gouty arthritis with dual-energy CT on Science Daily, >CLICK HERE.<


Filed under: Gout Diagnosis.

Tags: colchicine information, gout diagnose, diagnosing gouty arthris, dual-energy ct, colchicine.ca.


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Age Old Resin Proves a Natural Arthritis and Gout Medication

August 10, 2011 by Alex.

An age old substance could offer new hope for sufferers of inflammatory arthritis and the more common osteoarthritis. That substance is frankincense, a resin derived from the hardy Boswellia tree. Frankincense has been traded for over 5000 years, and is best known for its aroma. It is commonly used in incense and perfumes.

Frankincense is also widely used in various religious rites, and was said to be among the gifts presented to baby Jesus by the biblical Magi, or wise men, along with gold and myrrh (a similar reddish resin). Frankincense is still burned in the Roman Catholic Church.

Frankincense has also long been valued for its medicinal properties. The resin is edible, and is used in Asian traditional medicine to aid digestion and promote healthy skin. Frankincense has also been used in Ayurvedic (traditional Indian) medicine for hundreds of years, and is called dhoop. Dhoop is used for treating arthritis, healing wounds, strengthening the female hormonal system and combating germs and mosquitoes.

Scientists have been investigating frankincense as a treatment for chronic inflammatory conditions such as ulcerative colitis and Crohn's disease, asthma, cancer, and rheumatoid and osteoarthritis In 2008, researchers from John Hopkins University and the Hebrew University of Jerusalem reported that frankincense smoke was a psychoactive drug that relieved depression and anxiety in mice.

In another 2008 study at the University of California, 70 osteoarthritis patients taking a frankincense extract showed a significant improvement in their condition in less than seven days, with no major adverse effects. The extract was a proprietary product developed by Laila Nutraceuticals.

Recently, scientists from Cardiff University in Wales, noting that frankincense was a traditional herbal remedy for arthritis in the local Somali community, began to research it in the lab. Their research focused on whether and how extracts of frankincense could help reduce arthritic inflammation and reduce pain.

They were able to demonstrate that an extract of a rare frankincense species, Boswellia frereana, inhibited the production of key inflammatory molecules, helping to prevent the painful breakdown of cartilage that is characteristic of arthritis and gouty arthritis.

"What our research has managed to achieve is to use innovative chemical extraction techniques to determine the active ingredient in frankincense," explained Dr. Ahmed Ali, "Having done this, we are now able to further characterize the chemical entity and compare its success against other anti-inflammatory drugs used for treating the condition."

According to the Centers for Disease Control and Prevention (CDC), arthritis is the most common form of disability in the US, impacting nearly 21 million adults. Arthritis can be classified as either inflammatory or non-inflammatory. Inflammatory arthritis is characterized by the presence of inflammatory white blood cells in the joint fluid.

Gout is an inflammatory form of arthritis, as is rheumatoid arthritis. Osteoarthritis is a non-inflammatory form of the disease. Both forms are incurable, but can be managed with lifestyle changes and arthritis or gout medications. Check out the Colchicine video online.


Filed under: Gout Medications, Gout Natural Remedies, Gout Videos.

Tags: gout treatment, gout medication, gouty arthritis, anti-inflammatory drugs, buy colchicine, colchicine from Canada.


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Is Vitamin C a Natural Gout Remedy?

August 12, 2011 by Lynn.

Vitamin C is one of the best known and most readily available vitamins, and also one of the cheapest. John Mepham of www.best-gout-remedies.com has researched vitamin C as a natural remedy for gout, and written an e-book in which he shares his findings.

Mepham's research suggests that vitamin C is a helpful gout remedy that increases the body's ability to excrete uric acid. But he warns that the effect may be more subtle than gout sufferers would achieve with prescription gout medication. He also cautions that rapid changes in uric acid levels caused by Vitamin C or a prescription gout drug can trigger a painful gouty arthritis attack.

The 15-page report includes information on research on vitamin C for gout, recommendations for the use of the natural remedy as a gout medication and preventative, and dietary sources of Vitamin C.

To get a free copy of Mepham's Vitamin C and Gout Report, >CLICK HERE< and scroll down to the bottom of the page.


Filed under: Gout Natural Remedies.

Tags: colchicine, natural gout remedy, gout remedies, natural remedy for gout, gout remedy, gout medication, gout drug, gouty arthritis, colcrys.


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Experimental Gout Medication Outperforms Allopurinal

August 15, 2011 by Alex.

Spanish researchers have presented exciting findings to the 2011 European League Against Rheumatism (EULAR) Congress. An investigational gout medication, lesinurad, was able to achieve rapid and sustained reductions in urate levels in gout patients who did not receive the desired results with commonly used uric acid lowering medications.

"Lesinurad, a URAT1 inhibitor that increases the urinary excretion of uric acid, is a potential treatment option for patients with gout," said Dr. Fernando Perez-Ruiz, one of the Spanish researchers from the Hospital de Cruces, Baracaldo in Vizcaya.

Lenisurad has shown significant urate lowering activity both used alone and in combination with either prescription allopurinal (name brand Zyloprim) or febuxostat (Uloric). The Spanish study involved 208 gout patients who had high blood urate levels for at least 6 months, even while taking the gout drug allopurinol. Patients continued on allopurinol and were randomly assigned to receive either a placebo or lesinurad at doses of 200 mg, 400 mg, or 600 mg for four weeks.

All three groups who were given lesinurad showed significantly lower uric acid levels at the end of the month. The percentage of patients who achieved the target for uric acid levels after treatment was 28% in the placebo group, 71% in the 200 mg group, 76% in the 400 mg group, and 87% in the 600 mg group.

After the initial 4 weeks of treatment, 115 patients entered an extension phase in which most of them continued treatment with 200 mg of lesinurad. At week 28, 83% of the first 30 assessable patients were at target serum urate levels, with no serious adverse effects.

It's assumed that this lowering of uric acid levels will have a significant impact on the dissolving and reabsorption of gout tophi (deposits of crystallized uric acid) in the body.

New gout medications are few and far between, although there are currently at least eight gout drugs "in the pipeline". The first new gout drug to be approved in 40 years was febuxostat name brand Uloric) in 2009. In 2010 the FDA approved Krystexxa, an intravenous medication for chronic, severe gout that did not respond to other treatments.

The lesinurad mechanism of action is different than that of allopurinol and febuxostat. Both allopurinol and febuxostat are xanthine oxydase inhibitors which decrease the production of uric acid. Lesinurad is a uricosuric drug which increases elimination of uric acid through the kidneys.

Initial studies show that lesinurad may have significant advantages over another existing uricosuric drug, probenecid (Benemid), including less interaction with other drugs and more effectiveness in patients taking diuretics. This added benefit is because lesinurad is also active against another important regulator of urate secretion, OAT4. OAT4 is thought to be responsible for the high uric acid levels in gouty arthritis patients whose condition is caused or worsened by diuretics.


Filed under: Gout Medications.

Tags: colchicine, colcrys, gout medication, gout drug, prescription allopurinal, gout drug allopurinal, name brand Uloric, gout medications, lesinurad mechanism of action, gout drugs, gouty arthritis, colch.


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Does Caffeine Trigger Attacks of Gouty Arthritis?

August 17, 2011 by Estella.

The incidence of gouty arthritis doubled in the US between the 1960s and the 1990s, and that trend is continuing. Gout is feared as the most painful type of arthritis. It results from a build up of uric acid in the blood, which ends up deposited around the joint or joints in sharp, needle-like crystals, most often at the base of the big toe.

"Gout is the most common inflammatory arthritis in the US," says Dr. Tuhina Neogi, an associate professor at Boston University School of Medicine, "We have good gout medications that can potentially prevent attacks, yet people do still get attacks, with recurrent attacks being the biggest burden of gout."

While gout is considered a chronic, incurable disease, it can be managed with lifestyle changes and gout medications. Gout flare ups are highly associated with diet, particularly food rich in naturally occurring compounds called purines. Red meat, yeast, certain seafood and alcohol well-known gout triggers.

Researcher Neogi and her team were intrigued by earlier studies that found caffeine intake appeared to lower uric acid levels in the body over time, decreasing the risk of developing gout. But those studies were conducted with non-gout sufferers, and the team wondered about the effect of caffeine on people who already had gout.

Caffeine was of particular interest to the researchers because its chemical structure is very similar to a common uric acid lowering gout medication, allopurinol. While effective over time, allopurinol can trigger a gout attack in patients just starting to take the gout medicine.

This is because, as the uric acid crystals deposited in the joints begin to dissolve, they release uric acid into the blood stream. Neogi and her team wondered if caffeine might have the same short-term effect.

The team studied gout patients who drank caffeine-containing beverages like, coffee, tea, soft drinks and energy drinks. They found that caffeine "binges" did indeed trigger gout flare ups. In fact, gout patients who normally had a low caffeine intake who drank six caffeine containing drinks in a day tripled their risk of experiencing a gout attack within 24 hours.

However, those gout patients that normally drank more than two servings of caffeinated beverages a day had no reaction to increasing their consumption, much as a gout patient taking allopurinol for gout no longer experiences a flare up after the first few doses.

"I would not advise someone with gout to start drinking coffee as a way to lower uric acid levels due to its short-term effects," cautions Neogi. "People with gout who are already habitual caffeine drinkers probably don't need to change their habits, given that long-term caffeine intake can potentially lower uric acid levels. But the person who doesn't drink a lot of caffeine on a regular basis should be aware that drinking more than usual may potentially trigger an attack."


Filed under: Gout Arthritis.

Tags: colchicine, caffeine, gout attack, gouty arthritis, gout medications, gout medication, gout medication allopurinol, gout medicine, allopurinol for gout, lower uric acid, colchicine information, colchi.


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Gout Medication Krystexxa Given Intravenously

August 19, 2011 by Alex.

In 2010, the FDA approved the first and only gout medication to treat adults with chronic and severe gouty arthritis that didn't respond to existing gout drugs. The intravenous medication, Krystexxa (pegloticase), is derived from an animal hormone. The pegloticase mechanism of action is different than that of other gout medications - it converts uric acid to a nontoxic byproduct that is easily excreted in the urine.

Krystexxa is given as an intravenous infusion over at least two hours every two weeks. The FDA has warned that patients should be given a corticosteroid and antihistamine before infusions because of a high risk of allergic reaction. Other common side effects of Krystexxa are gout flare ups, nausea and vomiting, chest pain, constipation, nasal irritation and bruising at the injection site.

Despite these Krystexxa side effects, the FDA believes pegloticase is an important option for the 3% of gout patients that don't benefit from other gout medications such as prescription colchicine, allopurinol and febuxostat. Approximately 3 million Americans suffer from gouty arthritis.

Krystexxa was not studied in patients with congestive heart failure, and the FDA advises it should be used with caution in patients with the condition. Krystexxa is manufactured by Savient Pharmaceuticals, an American company based in New Jersey. For more information on the gout medication, visit krystexxa.com.


Filed under: Gout Medications.

Tags: colchicine, gout medication, krystexxa, pegloticase, gout drug, krystexxa side effects, prescription colchicine, gouty arthritis .


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Celery as a Natural Gout Remedy

August 22, 2011 by Lynn.

Celery has been used for centuries as a natural diuretic and anti-inflammatory. When it comes to gouty arthritis, celery is believed to act in much the same way as the gout drug allopurinal.

Gout is caused by excess uric acid in the body. Xanthine oxidase is an enzyme that plays a major role in the production of uric acid. Allopurinal is a xanthine oxidase inhibitor that reduces the creation of uric acid.

Studies in rats showed that celery may also inhibit xanthine oxidase. Two small human studies treating arthritis and gouty arthritis patients with celery extract also achieved positive results.

James Duke, PhD, a botanical consultant and former ethnobotanist, is the author of The Green Pharmacy. After Duke developed gout and was prescribed the gout medication allopurinol, he decided to try celery instead. He reported he kept his gout symptoms at bay using two to four tablets of celery extract a day, without taking allopurinol.

Celery's ability to both reduce swelling and increase the elimination of uric acid through the urine makes it a popular natural alternative to prescription gout medications. Herbalists advise that celery extract should not be taken by pregnant women, or by anyone with an allergy to celery.

To read some actual gout patients' comments on their experience with celery and celery seed on PeoplesPharmacy.com, >CLICK HERE.<

The author is not a medical expert, and this article should not be considered medical advice. Always consult your doctor before starting or discontinuing any prescription gout medication.


Filed under: Gout Natural Remedies.

Tags: colchicine, gout remedy, gouty arthritis, anti-inflammatory, gout drug, gout symptoms, gout drug allopurinal, gout medication, gout medication, gout medication allopurinal, gout medications, prescript.


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Eight Famous People with Gouty Arthritis

August 24, 2011 by Alex.

Gout is normally associated with portly historical figures such as King Henry the VIII. Benjamin Franklin missed several important meetings in which the Declaration of Independence was drafted due to gout flare ups, and had to be sent the documents to make his revisions.

But the rate of gout has doubled in the last 50 years, and remains on the rise. It now affects over 8 million Americans, most of them men, and many of them young and otherwise healthy, such as major league baseball pitcher Curt Schilling. Gout is considered the most painful form of arthritis and remains a chronic and incurable condition. Luckily, it can be managed with diet and gout medication.

Fellow pitcher David Wells said he gave a "high falsetto scream, like a six-year-old girl", when he woke up with his first attack of gout and stood up on the affected foot. To see which famous basketball player and soccer star suffer from gout, and which well known actor developed gouty arthritis after gaining 60 pounds for a role (ending up in a wheelchair), check out the Health.com slideshow, 8 Famous People With Gout.


Filed under: Gout Arthritis.

Tags: people with gout, celebrities with gout, gout celebrity, gout pain, gouty arthritis, gout medication, colcrys, colchicine.


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Epsom Salt Relieves Gouty Arthritis Pain

August 26, 2011 by Lynn.

Another popular natural remedy for the pain and inflammation of gout is Epsom salt. Epsom salt gets its name from the town of Epsom in England, where it is distilled from springs rising in an area where porous chalk hills meet non-porous clay. Epsom salt is composed of magnesium, sulpher and oxygen, and is also known by its chemical name, magnesium sulphate.

According to the Universal Health Institute of Chicago, magnesium is the second-most abundant element in human cells. The Institute says magnesium helps to regulate the activity of more than 325 enzymes, performing a vital role in orchestrating many bodily functions, from muscle control and electrical impulses to energy production and the elimination of harmful toxins.

American's magnesium levels have dropped more than 50% in the last century, and it's believed that most Americans are magnesium deficient. Magnesium deficiency is thought to play a role in arthritis and joint pain, heart disease, stroke, osteoporosis, digestive ailments, chronic fatigue and other ailments.

The Universal Health Institute says that magnesium also:

- Eases stress and improves sleep and concentration
- Helps muscles and nerves function properly
- Regulates activity of over 325 enzymes
- Helps prevent artery hardening and blood clots
- Allows the body to use insulin more effectively
- Reduces inflammation to relieve pain and muscle cramps
- Improves oxygen use

And that sulfates:

- Flush toxins
- Improve digestion and the absorption of nutrients
- Help form joint proteins, mucin proteins (mucus membrane secretions) and brain tissue
- Help prevent or ease migraine headaches

Both magnesium and sulphate can be absorbed through the skin, which is the body's largest organ. Epsom salt's ability to relax muscles, reduce swelling, relieve pain, fade bruises, draw out toxins and soften skin has made it the primary ingredient in most bath salts. Of special interest to gout patients, it also increases the secretion of uric acid through the skin.

Add two cups of Epsom salt to a standard size bathtub of warm water (or one cup to a warm footbath) and soak for at least twelve minutes two to three times a week (more often for foot baths). Some people claim adding one cup of vinegar (preferably apple cider) per every two cups of Epsom salt enhances its effects as a gout treatment. Soaking a gout-affected foot in a foot bath warm water and Epsom salt can provide almost immediate relief for many gout sufferers.

You can also make a compress by dissolving two cups of Epsom salt in a gallon of warm water, soaking a cloth or towel in it, and wrapping the cloth around the sore joint (in the case of gouty arthritis, usually the big toe). Some people use a thick sock to hold the compress against the effected area, but others can't stand the pressure of a sock on the sore joint. You can also cut the end off an old sock and use it to secure a compress applied to arthritic knees, wrists, and elbows.

Epsom salt is inexpensive, non-toxic, and readily available in drug and grocery stores. It makes an excellent addition to the gout sufferer's arsenal of natural gout remedies and prescription gout medication. For discover more uses of Epsom salt (some of which will surprise you) on www.care2.com >CLICK HERE.<


Filed under: Gout Natural Remedies, Gout Pain Relief.

Tags: gouty arthritis, gout pain, natural remedy, inflammation of gout, epsom salt, gout treatment, natural gout remedies, prescription gout medication, colchicine, colcrys.


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Bananas as a Natural Gout Treatment

August 29, 2011 by Estella.

Christine Marquette, a registered dietician from the Austin Regional Clinic, has produced an informational video titled Nutrition & Diets: About Bananas & Gout. In the video, Marquette explains why bananas are thought to decrease gout symptoms.

She attributes bananas' ability to act as a natural gout treatment to their high levels of potassium and vitamin C. Marquette points out that gout is caused by high levels of uric acid in the body, and a gouty arthritis flare up increases the acidity of the body.

Potassium helps regulate the body's acid-base balance (the normal equilibrium between acids and alkalis). The potassium in bananas may decrease the acidity in the body, making it more alkaline.

As well, the vitamin C in bananas has anti-inflammatory qualities that may help reduce the painful inflammation which always accompanies a gout attack. While she doesn't go so far as to say bananas could replace gout medication, Marquette does feel the fruit should be a part of any gout patient's diet.

To view the About Bananas & Gout video, >CLICK BELOW.


Filed under: Gout Treatment and Prevention, Gout Natural Remedies.

Tags: bannas, gout nutrition & diet, natural gout treatment, gout treatment, natural gout remedies, gout symptoms, gouty arthritis, gout medication.


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New Colchicine Safety Studies

August 31, 2011 by Lynn.

Recent results from a series of colchicine safety studies provide doctors with the first evidence-based dosing guidance for the gout drug when colchicine is prescribed along with certain common drugs, helping to avoid serious and potentially life-threatening drug interactions.

The study results were published in the August issue of Arthritis & Rheumatism, the journal of the American College of Rheumatology. The paper recommends colchicine dose reductions when used with medications such as immunosuppressants, antibiotics, hypertension drugs, anti-fungals and protease inhibitors.

To read more about the study results and the resulting recommendations on the URL Pharma website (manufacturer of the brand name colchicine Colcrys), >CLICK HERE.<


Filed under: Colchicine Safety.

Tags: colchicine safety, gout drug, gout prescription, arthritis drug, colchicine dose, brand name colchicine, colchicine medication, colchicine colcrys .


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